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The BTPABA pancreatic function test in giardiasis.

M Okada, T Fuchigami, S Ri

    Postgraduate Medical Journal
    |February 1, 1983
    PubMed
    Summary
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    Giardiasis significantly lowers N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BTPABA) test recovery, indicating impaired exocrine pancreatic function. Treatment eradicates this impairment, restoring normal pancreatic function.

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Pancreatic Physiology

    Background:

    • Exocrine pancreatic insufficiency can result from various conditions.
    • The N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BTPABA) test is a non-invasive method to assess pancreatic exocrine function.
    • Giardiasis is a common intestinal parasitic infection.

    Purpose of the Study:

    • To evaluate the impact of giardiasis on exocrine pancreatic function using the BTPABA test.
    • To determine if Giardia lamblia infection interferes with pancreatic chymotrypsin activity.
    • To assess the reversibility of pancreatic dysfunction after giardiasis treatment.

    Main Methods:

    • The BTPABA test was administered to 7 patients with giardiasis and 7 healthy controls.
    • Cumulative p-aminobenzoic acid (PABA) recovery was measured over 6 hours.

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  • PABA recovery was also assessed after administering free PABA to compare absorption.
  • BTPABA test results were compared before and after antiparasitic treatment in giardiasis patients.

    • Main Results:

    • Patients with giardiasis showed significantly lower PABA recovery compared to controls.
    • No difference in PABA recovery was observed when free PABA was administered, suggesting malabsorption was not the primary issue.
    • Post-treatment BTPABA test values in giardiasis patients significantly improved.
    • Eradication of Giardia lamblia normalized BTPABA test results, with no difference compared to healthy controls.

    Conclusions:

    • Giardia lamblia infection interferes with pancreatic chymotrypsin activity, leading to abnormal BTPABA test results.
    • Giardiasis can cause a temporary exocrine pancreatic dysfunction.
    • The BTPABA test is a valuable tool for detecting pancreatic dysfunction in giardiasis patients, and function normalizes after treatment.