Related Experiment Videos
[Affinity of N-formimidoyl-thienamycin (MK-0787) for beta-lactamases, analysis by a statistical method:
Annales De Microbiologie
|January 1, 1983
Abstract:
N-formimidoyl-thienamycin (MK-0787) is not subject to beta-lactamase hydrolysis. Nevertheless, this compound does show some affinity for the TEM-type penicillinases, cephalosporinases and a few other beta-lactamases. Surprisingly no affinity was found for the penicillinases of the CARB-type. The results thus obtained for affinity constants Ki and Km were submitted to a statistical analysis treatment, i.e. correspondence analysis and hierarchic ascendent classification. This confirms the fact that MK-0787 presents an unusual behaviour towards beta-lactamases.