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Related Experiment Videos

Occult systemic lupus erythematosus in elderly men.

A N Baer, T Pincus

    JAMA
    |June 24, 1983
    PubMed
    Summary

    Systemic lupus erythematosus (SLE) is often missed in older men with severe illness. Early DNA antibody testing can aid diagnosis and improve outcomes for these patients.

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    Arthritis care & research·2016

    Area of Science:

    • Rheumatology
    • Internal Medicine
    • Geriatrics

    Background:

    • Systemic lupus erythematosus (SLE) diagnosis can be challenging in elderly men, especially without prominent pleuropericarditis.
    • Initial presentations may mimic other systemic illnesses, leading to diagnostic delays.

    Purpose of the Study:

    • To highlight the diagnostic challenges of SLE in elderly men.
    • To evaluate the utility of early DNA antibody testing in this demographic.

    Main Methods:

    • Retrospective case series of five elderly men diagnosed with SLE.
    • Review of clinical presentations, diagnostic evaluations, and treatment responses.

    Main Results:

    • Patients presented with non-specific systemic symptoms like fever, weight loss, and arthritis.
    • Diagnosis was significantly delayed, requiring extensive investigations.
    • DNA antibodies were detected in four out of five patients.
    • Corticosteroid therapy was effective in three patients.

    Conclusions:

    • Systemic lupus erythematosus (SLE) should be considered in elderly men presenting with debilitating systemic illness.
    • Early screening for DNA antibodies can expedite diagnosis and facilitate timely treatment.
    • Prompt diagnosis and management can lead to improved patient outcomes.

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