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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

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Bone marrow involvement in histiocytosis X.

K McClain, N K Ramsay, L Robison

Medical and Pediatric Oncology

|January 1, 1983

Summary

Histiocytosis X (HX) bone marrow involvement in 18% of patients at diagnosis, linked to more severe symptoms and higher mortality. Trephine biopsies are superior for diagnosing marrow HX.

Area of Science:

Hematology
Pediatric Oncology
Pathology

Background:

Histiocytosis X (HX), a rare disorder involving abnormal proliferation of histiocytes.
Bone marrow involvement is a significant prognostic factor in HX.

Purpose of the Study:

To investigate the prevalence and clinical significance of bone marrow involvement in patients diagnosed with Histiocytosis X.
To determine if bone marrow involvement correlates with specific clinical features and patient outcomes.

Main Methods:

Retrospective review of bone marrow aspirates and trephine biopsies from 28 patients with Histiocytosis X at diagnosis.
Statistical analysis to compare clinical and laboratory findings between patients with and without bone marrow involvement.

Main Results:

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Bone marrow involvement was identified in 5 of 28 patients (18%).
Patients with bone marrow involvement showed a higher frequency of fever, splenomegaly, rash, diabetes insipidus, and lower platelet counts.
Two patients with bone marrow involvement died, compared to zero deaths in the other 23 patients.
Trephine biopsy sections were more effective for diagnosing marrow HX than aspiration smears.

Conclusions:

Bone marrow involvement at diagnosis in Histiocytosis X may indicate more extensive and potentially fatal disease.
Early identification of bone marrow involvement through trephine biopsy can aid in risk stratification and management decisions.