Related Experiment Videos
Propranolol does not further decrease the clearance of antipyrine in patients with alcoholic cirrhosis
Clinical Science (London, England : 1979)
|August 1, 1983
Summary
Propranolol did not further decrease antipyrine clearance in patients with alcoholic cirrhosis. This suggests hepatic metabolism of low clearance drugs may remain stable during propranolol therapy for gastrointestinal bleeding prevention.
Area of Science:
- Pharmacology
- Hepatology
- Gastroenterology
Background:
- Alcoholic cirrhosis significantly reduces antipyrine clearance, indicating impaired hepatic drug metabolism.
- Patients with alcoholic cirrhosis and gastrointestinal bleeding require careful management of drug therapies.
Purpose of the Study:
- To investigate the effect of propranolol on antipyrine clearance in patients with alcoholic cirrhosis and recent gastrointestinal bleeding.
Main Methods:
- Determined antipyrine clearance before and during propranolol administration in eight male patients with alcoholic cirrhosis.
- Compared antipyrine clearance in these patients to eight age-matched male control subjects.
Main Results:
- Antipyrine clearance was markedly reduced in patients with alcoholic cirrhosis compared to controls.
- One month of propranolol administration did not further decrease antipyrine clearance in these patients.
Conclusions:
- Propranolol therapy does not appear to further impair hepatic metabolism of low clearance drugs like antipyrine in patients with alcoholic cirrhosis.
- This finding has implications for the use of propranolol in preventing recurrent gastrointestinal bleeding in this patient population.