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Immune function among normal Guamanians of different age
Journal of Gerontology
|July 1, 1983
Summary
Immune function declines with age in Guamanian Chamorros, with fewer lymphocytes and T-cells. Serum IgA increased, while IgM decreased, suggesting a link between immunity and age-related diseases in this population.
Area of Science:
- Immunology
- Gerontology
- Population Health
Background:
- Guamanian Chamorros exhibit high prevalence of neurodegenerative diseases.
- Age-related changes in immune function are not fully understood in diverse populations.
Purpose of the Study:
- To investigate age-related differences in immune function among normal Guamanian Chamorros.
- To explore potential links between immune system changes and age-associated diseases.
Main Methods:
- Measured lymphocyte and T-cell counts and phytohemagglutinin (PHA) response.
- Assessed serum immunoglobulin A (IgA), G (IgG), and M (IgM) levels.
- Utilized regression analysis to correlate immune parameters with age (20-83 years).
Main Results:
- Significant negative correlations found between age and total lymphocytes/T-cells.
- A less significant negative correlation observed between age and PHA response.
- Serum IgA levels increased with age, IgM levels decreased, and IgG levels remained unchanged.
Conclusions:
- Normal Guamanian Chamorros show age-dependent alterations in immune function.
- These immunologic changes are less pronounced than those seen in Guamanians with neurodegenerative diseases.
- Findings suggest a potential etiological link between immune function and age-associated degenerative diseases in this population.