Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prolymphocytic leukemia: postmortem findings after long-term survival.

J Pacheco, N Hillman, J Lin

    Southern Medical Journal
    |July 1, 1983
    PubMed
    Summary

    A patient with prolymphocytic leukemia achieved a prolonged survival of 44 months. Treatment with acute myelocytic leukemia agents induced remissions, but B-cell surface markers indicated the leukemia

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The complementary roles of surface-immunoglobulin clonality and fluorescence intensity, mouse rosettes, and cd5 in the diagnosis of B-chronic lymphocytic-leukemia.

    International journal of oncology·2011
    Same author

    Chronic lymphocytic-leukemia with pleomorphic lymphocytes (cll-pleo) - a comparative-study with typical cll.

    International journal of oncology·2011
    Same author

    Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells.

    Gynecologic oncology·2000
    Same author

    Expression of inducible nitric oxide synthase (iNOS) in middle ear epithelial cells by IL-1beta and TNF-alpha.

    International journal of pediatric otorhinolaryngology·2000
    Same author

    An illustrated tutorial of musculoskeletal sonography: part 2, upper extremity.

    AJR. American journal of roentgenology·2000
    Same author

    MR imaging of anterior cruciate ligament reconstruction graft.

    AJR. American journal of roentgenology·2000

    Area of Science:

    • Hematology
    • Oncology
    • Immunophenotyping

    Background:

    • Prolymphocytic leukemia (PLL) is a rare, aggressive lymphoid malignancy.
    • Treatment strategies for PLL often differ based on cell lineage.

    Observation:

    • A patient diagnosed with prolymphocytic leukemia presented with unique clinical and immunophenotypic characteristics.
    • The patient received therapeutic agents typically employed for acute myelocytic leukemia (AML).

    Findings:

    • The patient achieved a partial remission lasting over 11 months and a brief complete remission.
    • Immunophenotypic analysis using surface markers definitively identified the leukemia as B-cell in origin.
    • Despite B-cell markers, AML-directed therapy induced a clinical response.

    Related Experiment Videos

    Implications:

    • This case highlights the importance of comprehensive immunophenotyping in diagnosing and managing lymphoid leukemias.
    • The findings suggest potential therapeutic strategies for B-cell PLL that may involve agents used in myeloid malignancies.
    • Further research is warranted to explore the efficacy of AML-targeted therapies in B-cell PLL.