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Related Experiment Videos

Complement activation in shock associated with a surgically provoked bacteriaemia.

I Brandslund, B Teisner, P Hole

    Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology
    |February 1, 1983
    PubMed
    Summary

    Anaphylactoid shock during a medical procedure was linked to complement system activation. This immune response involved both classical and alternative pathways, suggesting a bacterial antigen-antibody reaction.

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    Area of Science:

    • Immunology
    • Urology

    Background:

    • Transurethral coagulation of bladder tumors can precipitate adverse reactions.
    • The complement system is a crucial part of innate immunity, involving complex protein cascades.

    Observation:

    • A patient experienced anaphylactoid shock post-procedure.
    • Streptococcus faecalis was identified in urine and blood samples.
    • Complement activation was detected via C3d, C3c, and C4 levels.

    Findings:

    • Both classical and alternative complement pathways were activated.
    • Classical pathway activation suggested an antigen-antibody reaction.
    • Alternative pathway involvement indicated a broader immune response.

    Implications:

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  • Bacterial translocation into the bloodstream may trigger complement activation.
  • This immune response could be responsible for anaphylactoid shock in susceptible patients.
  • Understanding complement activation is vital for managing procedural complications.