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Uric acid excretion in normal children.

F B Stapleton, M A Linshaw, K Hassanein

    The Journal of Pediatrics
    |June 1, 1978
    PubMed
    Summary
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    Urinary uric acid excretion and serum levels rise during childhood. Fractional excretion and clearance of uric acid decrease with age, suggesting tubular maturation in children.

    Area of Science:

    • Pediatric Nephrology
    • Renal Physiology
    • Uric Acid Metabolism

    Background:

    • Uric acid is a key metabolic byproduct.
    • Understanding its excretion and clearance is vital for pediatric kidney health.
    • Normative data in children are essential for diagnosing renal abnormalities.

    Purpose of the Study:

    • To establish standard values for urinary uric acid excretion and clearance in healthy children.
    • To investigate the developmental changes in uric acid handling throughout childhood.
    • To explore the relationship between age, filtered uric acid load, and tubular function.

    Main Methods:

    • Recruitment of 95 normal, nonhospitalized children.
    • Measurement of urinary uric acid excretion.

    Related Experiment Videos

  • Calculation of serum uric acid values, fractional excretion, and clearance.

    • Main Results:

    • Urinary uric acid excretion and serum uric acid values increase with age in children.
    • Fractional excretion and clearance of uric acid are higher in early childhood compared to adult norms.
    • Despite increased filtered uric acid load, fractional excretion and clearance progressively decline with advancing age.

    Conclusions:

    • Tubular maturation, involving decreased secretion or increased reabsorption of uric acid, occurs during childhood.
    • These findings highlight significant developmental changes in renal uric acid handling.
    • Standard values are crucial for assessing pediatric renal function related to uric acid.