Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemodynamic changes during protamine administration.

I A Michaels, P G Barash

    Anesthesia and Analgesia
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pulmonary artery catheter under the microscope.

    Critical care medicine·2001
    Same author

    "AAA" to the rescue?

    Critical care medicine·2000
    Same author

    Governmental databases, hospital information systems, and clinical outcomes: big brother or big help?

    Anesthesia and analgesia·1999
    Same author

    Pro: All elective coronary artery bypass grafting patients are American Society of Anesthesiologists' Physical Status IV.

    Journal of cardiothoracic and vascular anesthesia·1999
    Same author

    The use of relational databases in the transition from quality assurance to continuous quality improvement: a clinical practice model.

    American journal of medical quality : the official journal of the American College of Medical Quality·1998
    Same author

    Percutaneous transluminal coronary angioplasty before noncardiac surgery: current state of the debate.

    Journal of cardiothoracic and vascular anesthesia·1998
    Same journal

    Incomplete Recovery of Diaphragmatic Mechanics at a Train-of-Four Ratio of 0.90 to <0.95 Assessed by Dynamic Digital Radiography: A Proof-of-Concept Case Series.

    Anesthesia and analgesia·2026
    Same journal

    Patients' Perspectives and Experiences of Participating in Anesthesia Research: A Qualitative Study.

    Anesthesia and analgesia·2026
    Same journal

    Impact of Epidural-Related Maternal Fever on Neonatal Outcomes: A Single-Center Retrospective Case-Control Study Excluding Confirmed Histological Chorioamnionitis.

    Anesthesia and analgesia·2026
    Same journal

    Patient Beliefs and Experiences of Adhering to Medical Therapies for Cardiovascular Comorbidities, Before Noncardiac Elective Surgery in South Africa: A Mixed-Methods Study.

    Anesthesia and analgesia·2026
    Same journal

    Beyond Administrative Indices: Allostatic Load and Autonomic Dyshomeostasis as Biological Mediators of Intraoperative Cardiac Arrest.

    Anesthesia and analgesia·2026
    Same journal

    In Response.

    Anesthesia and analgesia·2026
    See all related articles

    Protamine sulfate administration can cause adverse hemodynamic effects, particularly in patients with poor left ventricular function post-cardiopulmonary bypass. Caution is advised when administering protamine to these vulnerable patients.

    Area of Science:

    • Cardiology
    • Anesthesiology
    • Pharmacology

    Background:

    • Protamine sulfate is used to reverse heparin anticoagulation.
    • Its hemodynamic effects, especially in vulnerable patient populations, require thorough investigation.

    Purpose of the Study:

    • To evaluate the hemodynamic responses to intravenous protamine sulfate administration.
    • To assess the impact of protamine on patients with varying degrees of left ventricular function after cardiopulmonary bypass.

    Main Methods:

    • Hemodynamic parameters were monitored in 40 patients receiving protamine sulfate.
    • Patients received protamine at rates of 0.5 mg/kg/min or 1 mg/kg/min.
    • Measurements were taken before, during, and after protamine infusion.

    Related Experiment Videos

    Main Results:

    • No significant hemodynamic changes were observed in patients with good left ventricular function.
    • Patients with poor left ventricular function experienced systemic vasodilation and a 12% decrease in mean blood pressure.
    • The vasodilation in patients with poor left ventricular function was inadequately compensated by increased cardiac index.

    Conclusions:

    • Protamine sulfate administration can induce significant hypotension in patients with compromised left ventricular function post-cardiopulmonary bypass.
    • Cautious administration of protamine is recommended for patients with poor left ventricular function.
    • Further research may explore optimal dosing or alternative strategies for this patient group.