Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell lymphoma-leukemia. Pathologic observations in three cases.

C C Whitcomb, J E Olivella, G E Byrne

    Cancer
    |October 1, 1983
    PubMed
    Summary

    A rare T-lymphocyte cancer causes enlarged lymph nodes and unique leukemic cells. This condition, marked by convoluted nuclei and hypercalcemia, may have shared origins due to geographic case clusters.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Treatment of AIDS-related primary central nervous system lymphoma with zidovudine, ganciclovir, and interleukin 2.

    AIDS research and human retroviruses·1999
    Same author

    Ocular-adnexal lymphoid tumors: a clinicopathologic and molecular genetic study of 77 patients.

    Ophthalmic plastic and reconstructive surgery·1999
    Same author

    Is central nervous system prophylaxis necessary in ocular adnexal lymphoma?

    Critical reviews in oncogenesis·1999
    Same author

    Post-transplant lymphoproliferative disease in kidney transplant patients in the new immunosuppressive era.

    Clinical transplantation·1997
    Same author

    Human herpesvirus type 8 DNA sequences in cell-free plasma and mononuclear cells of Kaposi's sarcoma patients.

    The Journal of infectious diseases·1996
    Same author

    Clinical spectrum of HTLV-I in south Florida.

    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association·1995

    Area of Science:

    • Hematology
    • Oncology
    • Immunology

    Background:

    • A recently identified neoplastic proliferation of T-lymphocytes presents with lymphadenopathy.
    • This condition is characterized by distinctive leukemic cells and unique histopathologic features in lymph nodes.

    Observation:

    • The abnormal T-lymphocytes exhibit considerable size variation.
    • A key feature is the presence of strikingly convoluted and lobulated nuclei in the neoplastic cells.
    • Hypercalcemia is a frequently observed complication associated with this neoplasm.

    Findings:

    • Histopathologic examination reveals lymph node features that can mimic other lymphoproliferative disorders.
    • The distinct cellular morphology, particularly nuclear convolution, aids in identification.
    • Geographic clustering of cases suggests potential common pathogenetic factors.

    Implications:

    • Understanding the unique cellular and clinical features is crucial for accurate diagnosis and differentiation from similar disorders.
    • Further research into potential common pathogenetic factors may elucidate the etiology of this T-lymphocyte neoplasm.
    • Investigating the link between geographic clustering and disease development could reveal environmental or infectious triggers.

    Related Experiment Videos