T-cell lymphoma-leukemia. Pathologic observations in three cases

A neoplastic proliferation of T-lymphocytes with manifestations of lymphadenopathy and distinctive leukemic cells has been described recently. Histopathologic features of involved lymph nodes are quite distinctive, but mimic some features of other lymphoproliferative disorders. The abnormal cells vary considerably in size, but are characterized by strikingly convoluted and lobulated nuclei. Hypercalcemia is a frequent complication of this neoplasm. Geographic clustering of reported cases has raised the possibility of common pathogenetic factors.