A follow-up of the "low dose suppressible" hypercortisolism

Five subjects with elevated excretion of urinary free cortisol but normal suppressibility to 2 mg dexamethasone test (i.e. with a "low dose suppressible" hypercortisolism) were followed over a period of one to three years. Two of them progressed into a typical pituitary-dependent Cushing's syndrome, whereas in three subjects a spontaneous regression of hypercortisolism was ascertained. A "low dose suppressible" hypercortisolism could therefore denote an early stage of Cushing's syndrome.