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Related Experiment Videos

In- 111-labeled leukocyte imaging: false-positive study due to acute gastrointestinal bleeding.

M F Fisher, T G Rudd

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |September 1, 1983
    PubMed
    Summary

    Indium-111 labeled leukocytes can accumulate in the colon due to upper gastrointestinal bleeding. This case highlights a potential diagnostic pitfall in nuclear medicine imaging.

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    Area of Science:

    • Nuclear Medicine
    • Diagnostic Imaging
    • Gastroenterology

    Background:

    • Nuclear imaging with Indium-111 labeled leukocytes is a common diagnostic tool.
    • Leukocyte scans are typically used to detect infection or inflammation.
    • Accurate interpretation relies on understanding potential sites of physiological or pathological accumulation.

    Observation:

    • A patient presented with unexpected accumulation of Indium-111 labeled leukocytes in the left colon.
    • This finding was observed on a 24-hour delayed imaging sequence.
    • The accumulation was identified as secondary to an active upper gastrointestinal bleed.

    Findings:

    • The study reports a rare case of radiolabeled leukocyte accumulation in the colon.
    • The observed colonic uptake was directly correlated with an ongoing upper gastrointestinal hemorrhage.

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  • This indicates that gastrointestinal bleeding can mimic inflammatory or infectious processes on leukocyte scintigraphy.

    • Implications:

    • Clinicians should consider upper gastrointestinal bleeding as a differential diagnosis for colonic leukocyte accumulation.
    • This finding emphasizes the importance of correlating imaging results with clinical presentation.
    • Proper interpretation of Indium-111 labeled leukocyte scans requires awareness of non-infectious causes of radiotracer uptake.