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Mechanism of resistance to some cephalosporins in Staphylococcus aureus

M Kono, M Sasatsu, K O'Hara

Antimicrobial Agents and Chemotherapy

|June 1, 1983

Abstract:

The mechanism of resistance to some cephalosporins in Staphylococcus aureus strains was investigated with high-pressure liquid chromatography and nuclear magnetic resonance spectrometry. Drug inactivation by penicillinase was found to be the main mechanism of resistance to cefazolin, cephaloridine, and cephalothin in S. aureus.

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