Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interleukin 2].

T Hirano

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Interleukin 2 (IL2) drives T cell growth and function via specific receptors. Cloning IL2 cDNA enables pure IL2 production for reevaluating its true biological roles and therapeutic potential.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth.

    Journal of immunology (Baltimore, Md. : 1950)·1992
    Same author

    Cytotoxic effects of cyclosporin A on the exocrine pancreas in rats.

    Surgery, gynecology & obstetrics·1992
    Same author

    Effect of ethanol on pancreatic secretion of lysosomal enzyme stimulated by pancreatic secretagogues in rats.

    Gastroenterologia Japonica·1992
    Same author

    [The cellular and lysosomal fragility of pancreatic acinar cells after ligation of pancreatico-biliary duct in the rat and the protective effects of nafamostat mesilate].

    Nihon Geka Gakkai zasshi·1992
    Same author

    [Vascular proliferation in the stroma of gastric cancer and its significance].

    Nihon Geka Gakkai zasshi·1992
    Same author

    Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells.

    International immunology·1992

    Area of Science:

    • Immunology
    • Molecular Biology
    • Cell Biology

    Context:

    • Interleukin 2 (IL2) discovered in 1976, crucial for T cell proliferation.
    • IL2 function mediated by specific receptors on antigen-activated T cells.
    • T cell clones and receptor studies advanced by IL2 research.

    Purpose:

    • To explore the biochemical and functional properties of IL2.
    • To understand IL2's mechanism of action via its receptor.
    • To reevaluate IL2 functions using pure, cloned cDNA-derived IL2.

    Summary:

    • Human IL2 cDNA cloning by Taniguchi et al. enabled pure IL2 production.
    • IL2 acts like a peptide hormone, binding to specific receptors on T cells.
    • Antigen-specific T cell responses are regulated by IL2 receptor expression.

    Impact:

    • Facilitates reevaluation of previous IL2 studies using impure preparations.
    • Opens avenues for investigating IL2's in vivo effects.
    • Promotes potential clinical applications of IL2 and other lymphokines in cancer therapy.