Serum myoglobin concentration as an index of myocardial damage after cardiac surgery

We assessed serum myoglobin concentration as an index of myocardial damage after cardiothoracic surgery in a dog model and man. Experimentally, we compared 12 dogs subject to left thoracotomy either with or without coronary artery ligation to cause an infarct. Serial blood sampling for 24 hours after surgery showed that the times taken for the myoglobin peak concentrations to appear distinguished the two groups without overlap. These times were 2.4 +/- 0.4 hours after surgery without ligation compared with 9.8 +/- 0.8 hours in the ligated group (P less than 0.001). Clinically, serial sampling was performed over 48 hours in 20 patients having undergone cardiac surgery involving cardiopulmonary bypass. A further 80 patients were investigated for 12 hours. Myoglobin was compared with the activities of creatine kinase, 2-hydroxybutyrate dehydrogenase and glutamate-oxaloacetate transaminase in relation to electrocardiographic criteria of myocardial damage. A myoglobin peak greater than 800 micrograms/1 appearing later than 6 hours after starting bypass was found in those patients suffering myocardial damage. The appearance times and activities of the enzymes tested were widely scattered and difficult to interpret. We conclude that blood samples taken at approximately 3 and 6 hours after starting bypass should suffice to characterise both peak myoglobin and its time of appearance which together form a sensitive index of myocardial damage. However, this conclusion is limited by the low incidence of myocardial damage (3%) in this group of patients.