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Related Experiment Videos

Ankylosing spondylitis: a family study.

S A LeClercq, L Chaput, A S Russell

    The Journal of Rheumatology
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    First-degree relatives of HLA-B27 positive spondylitis patients showed associated diseases, but sacroiliitis was less common than previously thought. This suggests over-estimation of disease prevalence in HLA-B27 positive individuals.

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    [Reversible posterior leukoencephalopathy syndrome in a patient presenting granulomatosis with polyangiitis].

    Annales de dermatologie et de venereologie·2016

    Area of Science:

    • Immunogenetics
    • Rheumatology
    • Ophthalmology

    Background:

    • The human leukocyte antigen B27 (HLA-B27) gene is strongly associated with spondyloarthropathies.
    • Previous studies suggested a high prevalence of associated diseases in HLA-B27 positive individuals.

    Purpose of the Study:

    • To investigate the prevalence of associated diseases and sacroiliitis in first-degree relatives of HLA-B27 positive spondylitis probands.
    • To re-evaluate the disease prevalence in HLA-B27 positive individuals.

    Main Methods:

    • Analysis of first-degree relatives of HLA-B27 positive spondylitis patients.
    • Clinical assessment for spondyloarthropathies and acute anterior uveitis.
    • Radiographic evaluation for sacroiliitis.
    • HLA-B27 typing.

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    Main Results:

    • 10.2% of first-degree relatives of HLA-B27 positive spondylitis probands had associated diseases (ankylosing spondylitis, Reiter's syndrome, peripheral arthritis, or acute anterior uveitis), all of whom were HLA-B27 positive.
    • 13.7% of HLA-B27 positive subjects had sacroiliitis, with 4 being asymptomatic.
    • No HLA-B27 negative relatives exhibited uveitis or spondyloarthropathy.

    Conclusions:

    • The prevalence of associated diseases and sacroiliitis in first-degree relatives of HLA-B27 positive spondylitis patients is lower than previously estimated.
    • Caution is advised against over-estimating disease prevalence in randomly selected HLA-B27 positive individuals.
    • HLA-B27 negativity appears protective against developing spondyloarthropathy and uveitis in this cohort.