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Updated: Aug 17, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

The MO/NK cell: an inducer of HLA-independent graft-versus-host disease?

L Delmonte

    Progress in Clinical and Biological Research
    |January 1, 1983
    PubMed

    We have described the MO/NK cell assay, a model for detecting non-HLA allodisparities between donor and host cells in co-culture prior to BMT. Generation of CFUc-inhibitory activity in MO/NK cells in this system is predictive of GvHD. We have also described a modified 3-step model in which allosensitized donor MO/NK cells induce autologous T cells to develop CFUc-inhibitory activity. This model may reflect the mechanism of induction of alloreactive donor-type T cells in HLA-matched BMT recipients who develop GvHD. The MO/NK cell assay could become a useful tool for improved donor:host matching or for identifying high-risk BMT recipients who might benefit from early institution of vigorous anti-GvHD prophylaxis. The 3-step model could provide a useful tool for studying cellular interactions leading to GvHD and for assessing effects of anti-GvHD agents on individual cellular components of GvH reactions.

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