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Pneumonia and acute febrile tracheobronchitis due to haemophilus influenzae

D M Musher, K R Kubitschek, J Crennan

    Annals of Internal Medicine
    |October 1, 1983
    PubMed

    Insights

    Nontypable Haemophilus influenzae commonly causes pneumonia and tracheobronchitis. Lowered opsonizing antibody activity may increase susceptibility to these pulmonary infections.

    Area of Science:

    • Infectious Diseases
    • Immunology
    • Pulmonology

    Background:

    • Haemophilus influenzae is a significant cause of pneumonia.
    • Nontypable strains are frequently implicated in respiratory infections.

    Purpose of the Study:

    • To investigate the characteristics of Haemophilus influenzae infections in pneumonia patients.
    • To explore host immune factors contributing to susceptibility.

    Main Methods:

    • Analysis of 30 pneumonia patients with Haemophilus influenzae infection.
    • Assessment of bacterial isolates, blood cultures, and patient antibody levels (bactericidal and opsonizing).

    Main Results:

    • Nontypable H. influenzae predominated (26/30 cases).
    • 14 patients had febrile purulent tracheobronchitis without radiographic infiltrate.
    • Patients showed reduced opsonizing activity against their infecting organism, which improved post-infection.

    Conclusions:

    • Nontypable H. influenzae, particularly Biotype I, is a common cause of pneumonia.
    • Deficient opsonizing antibody activity may predispose individuals to H. influenzae pulmonary infections.
    • Both bacterial and host factors influence susceptibility to H. influenzae pulmonary disease.

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