Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early histopathologic changes in experimentally replanted extremities.

B H Press, R K Sibley, A R Shons

    The Journal of Hand Surgery
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patient tolerability during office cystoscopy and bladder tumor cauterization: a multivariate analysis of risk factors.

    Actas urologicas espanolas·2022
    Same author

    Surveillance and office management of low-grade Ta bladder tumors.

    Actas urologicas espanolas·2022
    Same author

    Postmastectomy breast reconstruction: current techniques.

    Cancer control : journal of the Moffitt Cancer Center·2001
    Same author

    The effect of sentinel node selective axillary lymphadenectomy on the incidence of postmastectomy pain syndrome.

    Cancer control : journal of the Moffitt Cancer Center·2001
    Same author

    Breast cancer: advances in surgical management.

    Plastic and reconstructive surgery·2001
    Same author

    Expression of insulin-like growth factor-I and transforming growth factor-beta in hypokalemic nephropathy in the rat.

    Kidney international·2001
    Same journal

    The Diagnosis and Management of Clenched Fist Syndrome.

    The Journal of hand surgery·2026
    Same journal

    Ultrasound-Assisted Thin Posteromedial Thigh Free Flap for Coverage of Hand and Upper-Extremity Wounds.

    The Journal of hand surgery·2026
    Same journal

    Comparison of One- and Two-knot Techniques in Eight-Strand Flexor Tendon Repair Using Looped Sutures: A Biomechanical Study in a Porcine Model.

    The Journal of hand surgery·2026
    Same journal

    Biomechanical Comparison of Metal Versus Suture and Screw Tension Band Technique for Olecranon Fractures.

    The Journal of hand surgery·2026
    Same journal

    Incidence, Timing, and Predictors of Staged Contralateral Carpal Tunnel Release at Minimum Ten-Year Follow-Up from Unilateral Surgery.

    The Journal of hand surgery·2026
    Same journal

    Upper Limb Reconstruction in Arthrogryposis Multiplex Congenita: A Systematic Review.

    The Journal of hand surgery·2026
    See all related articles

    Histologic changes after limb replantation were studied in rats. Early ischemia evolved into denervation-like lesions, suggesting nerve damage contributes to poor functional outcomes in clinical replantations.

    Area of Science:

    • Reconstructive surgery
    • Histopathology
    • Microsurgery

    Background:

    • Early histologic changes in replanted extremities are not well understood.
    • The contribution of these changes to suboptimal functional results is unknown.

    Purpose of the Study:

    • To investigate early serial histologic changes in replanted extremities.
    • To correlate these changes with functional outcomes in a rat model.

    Main Methods:

    • A rat hind limb replantation model was utilized.
    • Tissues were examined using light microscopy from 1 to 60 days post-replantation.

    Main Results:

    • Early lesions were consistent with ischemic injury.
    • Chronic preparations showed normal histology, with lesions resembling denervation.

    Related Experiment Videos

  • Poor function in clinical replantations may mirror these pathologic findings.

    • Conclusions:

    • Histologic changes in replanted extremities evolve over time.
    • Denervation-like pathology may be a significant factor in poor functional outcomes.
    • Further research into mitigating these changes is warranted.