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Related Experiment Videos

Biphasic changes in hemoglobin A1c concentrations during normal human pregnancy.

R L Phelps, G R Honig, D Green

    American Journal of Obstetrics and Gynecology
    |November 15, 1983
    PubMed
    Summary

    During pregnancy, hemoglobin A1c levels show a biphasic pattern, declining then rising, mirroring changes in blood sugar regulation. These shifts remain within normal ranges for healthy pregnancies.

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    Area of Science:

    • Reproductive Endocrinology
    • Metabolic Physiology
    • Clinical Biochemistry

    Background:

    • Hemoglobin A1c (HbA1c) reflects average blood glucose over 2-3 months.
    • Understanding glycemic changes during pregnancy is crucial for maternal and fetal health.

    Purpose of the Study:

    • To investigate changes in hemoglobin A1c (HbA1c) concentrations throughout normal gestation.
    • To correlate HbA1c trends with plasma glucose levels during pregnancy.

    Main Methods:

    • HbA1c levels were analyzed in 377 nondiabetic pregnant women.
    • Plasma glucose was measured 1 hour after a 50 gm oral glucose load in 1,756 pregnant women.

    Main Results:

    • A biphasic pattern in HbA1c was observed: a decline to 24 weeks, followed by an increase near term.

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  • Plasma glucose showed a similar biphasic pattern, with a nadir at 20 weeks' gestation.
  • All observed HbA1c changes were within normal physiological ranges.

    • Conclusions:

    • The observed biphasic HbA1c changes reflect underlying alterations in mean blood sugar during pregnancy.
    • These findings highlight dynamic changes in glucose regulation throughout normal gestation.