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[Lymphocyte subpopulations in the cerebrospinal fluid: III. Normal values]
Arquivos De Neuro-Psiquiatria
|June 1, 1983
Summary
This study characterizes lymphocyte subpopulations in cerebrospinal fluid (CSF) from normal controls. The findings provide a reference for T-lymphocyte and B-lymphocyte subsets in CSF, aiding immunological studies.
Area of Science:
- Immunology
- Neuroscience
- Cell Biology
Context:
- Cerebrospinal fluid (CSF) analysis is crucial for diagnosing neurological conditions.
- Characterizing lymphocyte subpopulations in CSF provides insights into the central nervous system's immune status.
- Existing methodologies may face limitations with normal cell counts in CSF samples.
Purpose:
- To establish reference ranges for lymphocyte subpopulations in normal human CSF.
- To validate a methodology for characterizing CSF lymphocytes applicable even with low cell counts.
- To investigate the potential of CSF lymphocyte profiles in understanding immunological activation.
Summary:
- A methodology was applied to CSF samples from 50 normal controls to characterize lymphocyte subpopulations.
- Reference data (mean +/- SD) were obtained for B-lymphocytes (7.0 +/- 1.44%), T-lymphocytes (76.0 +/- 2.92%), and various T-cell subsets.
- The study suggests that the difference between T-lymphocytes and T-active lymphocytes may indicate immunological activation and identifies potential roles for killer lymphocytes.
Impact:
- Provides essential reference values for lymphocyte subpopulations in normal CSF.
- Enables more accurate immunological assessments in neurological disorders.
- May facilitate the identification of immune-related biomarkers in CSF for disease diagnosis and monitoring.