Amiloride inhibits anti-Ig induction of proliferation in a human B-lymphoma cell population
Related Experiment Video
Updated: Aug 10, 2026

11:55
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Experimental Cell Research
|November 1, 1983
Abstract:
The effects of amiloride on increased 86Rb+ influx, an early event of lymphocyte activation, and on the late event, [3H]thymidine uptake, were compared in anti-Ig-stimulated human B-lymphoma cells in vitro. Both events were inhibited to significant and comparable extents, and the drug effects were apparently not due to unspecific toxicity. This suggests that the increased 86Rb+ influx reflects early changes (e.g. amiloride-sensitive Na+-H+ exchange) which are required for anti-Ig induction of B-lymphocyte proliferation.

