A Fujita--Ban structure--activity analysis of 44 steroids

A Fujita--Ban structure--activity analysis has been performed on 44 steroids with a common pregn-4-ene-3,20-dione structure. The measured biological activity was glycogen deposition in the liver, expressed relative to the activity of cortisol. Substituents are at positions 2, 6, 9alpha, 11beta, 16alpha, 17, and 21. Substituents of positions 2, 6, and 17 accounted for 60% of the total variance. The substituents with significance at the p less than 0.01 level were 6alpha-hydrogen, 6alpha-methyl, 2alpha-hydrogen, 9alpha-fluorine, and 9alpha-hydrogen.