Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukins in experimental autoimmune disease.

N Talal, M Fischbach

    Advances in Experimental Medicine and Biology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Tick-borne encephalitis in a child in a nonendemic country: A case report].

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2016
    Same author

    [Purulent corneal melting: An unexpected complication of acute otitis media].

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2016
    Same author

    [Hodgkin disease revealed by a nephrotic syndrome: A case report].

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2015
    Same author

    [Erratum to "Medication adverse events: Impact of pharmaceutical consultations during the hospitalization of patients" [Ann. Pharm. Fr. 72 (2014) 440-450].]

    Annales pharmaceutiques francaises·2015
    Same author

    Cell transformation assays as predictors of human carcinogenicity.

    Alternatives to laboratory animals : ATLA·2014
    Same author

    [Medication adverse events: Impact of pharmaceutical consultations during the hospitalization of patients].

    Annales pharmaceutiques francaises·2014

    New mouse models for systemic lupus erythematosus (SLE) show reduced T cell proliferation. This defect stems from the T cells themselves, potentially due to impaired Interleukin-2 (IL-2) production in autoimmune mice.

    Area of Science:

    • Immunology
    • Autoimmunity
    • Genetics

    Background:

    • Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune system attacking self-tissues.
    • New mouse models, such as those with the lpr gene, exhibit key SLE features like autoantibodies and immune complex glomerulonephritis.
    • A common finding in these autoimmune mice is a defect in Interleukin-2 (IL-2) production.

    Purpose of the Study:

    • To investigate T cell proliferation defects in different mouse models of SLE.
    • To identify whether the defect lies within T cells or macrophages in lpr mice.
    • To explore the potential role of Interleukin-2 (IL-2) in T cell dysfunction in SLE.

    Main Methods:

    • Utilized an antigen presentation system to assess T cell proliferation.

    Related Experiment Videos

  • Compared T cell responses in MRL/lpr, C57B16/lpr, and C3H/He/lpr mice against their normal congenic counterparts.
  • Conducted mixing experiments involving T cells and macrophages from normal and lpr mice.

    • Main Results:

    • Normal congenic mice exhibited robust T cell proliferation.
    • Mice with the lpr gene showed significantly reduced T cell proliferation.
    • Mixing experiments indicated that the proliferation defect is intrinsic to the lpr T cells, not the macrophages.

    Conclusions:

    • The lpr gene in mice leads to impaired T cell proliferation, a hallmark of SLE.
    • The defect resides within the T cells of lpr mice, suggesting an intrinsic cellular abnormality.
    • Defective Interleukin-2 (IL-2) production by Lyt 1+23- T cells is a likely cause of the observed T cell dysfunction in these SLE models.