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Related Experiment Videos

Serum immunoglobulin and complement alterations in interstitial cystitis.

J Mattila, A Harmoinen, O Hällström

    European Urology
    |January 1, 1983
    PubMed
    Summary

    Patients with interstitial cystitis show significantly lower levels of complement component C4 and higher levels of immunoglobulin G. These findings suggest a role for the complement system in interstitial cystitis pathogenesis.

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    Area of Science:

    • Immunology
    • Urology
    • Biochemistry

    Background:

    • Interstitial cystitis (IC) is a chronic bladder condition with unknown etiology.
    • Immune system dysregulation is suspected in IC pathogenesis.

    Purpose of the Study:

    • To investigate potential immunological markers in interstitial cystitis patients.
    • To assess serum levels of immunoglobulins and complement components in IC.

    Main Methods:

    • Sera from 41 interstitial cystitis patients were analyzed.
    • Levels of IgA, IgG, IgM, C1q, C3, C4, and C1-esterase inhibitor were quantified.

    Main Results:

    • A statistically significant depletion of complement component C4 was observed (p < 0.001).

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  • Serum immunoglobulin G levels were markedly elevated (p < 0.001).

    • Conclusions:

    • Results suggest activation of the classical complement pathway in interstitial cystitis.
    • Findings support the hypothesis of a chronic local immunological process in IC pathogenesis.