Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computerized drug dosing in renal failure: a real problem and a practical solution.

A G Greenburg, W Adachi, D K McClure

    The Journal of Trauma
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Should we be wary of hernia mesh devices with reinforcement?: Invited Comment to: - The ONSTEP inguinal hernia repair technique: initial clinical experience of 693 patients, in two institutions. Lourenço A, Soares da Costa R. HERN 10.1007/s10029-013-1057-z. - Open preperitoneal inguinal hernia repair using a mesh with nitinol memory frame. Berrevoet F, Vanlander A, Bontinck J, Troisi RI. HERN 10.1007/s10029-013-1110-y.

    Hernia : the journal of hernias and abdominal wall surgery·2013
    Same author

    The past and present as prologue to the future: Comment on "Profile of inpatient operating room procedures in US hospitals in 2007".

    Archives of surgery (Chicago, Ill. : 1960)·2011
    Same author

    Reconstructing hemoglobin-based oxygen carriers.

    Transfusion·2010
    Same author

    Clinical contextualization and the assessment of adverse events in HBOC trials.

    Artificial cells, blood substitutes, and immobilization biotechnology·2008
    Same author

    A case of pill-induced esophagitis with mucosal dissection.

    Diagnostic and therapeutic endoscopy·2008
    Same author

    Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia.

    Journal of lower genital tract disease·2006

    Physicians often overdose medications in patients with impaired renal function. Using computer programs and creatinine clearance for dose adjustments can prevent medication toxicity and improve patient safety.

    Area of Science:

    • Pharmacology
    • Nephrology
    • Clinical Pharmacy

    Background:

    • Impaired renal function necessitates medication dose adjustments to prevent toxicity.
    • Physician dosing practices may not consistently account for renal function.
    • Accurate dose calculation is crucial for patient safety, especially with renally excreted drugs.

    Purpose of the Study:

    • To compare physician-determined drug doses with computer-generated recommendations in patients with impaired renal function.
    • To identify the incidence of medication overdosing based on physician judgment versus computer-assisted dosing.
    • To evaluate the potential hazards associated with incorrect drug dosing in renal impairment.

    Main Methods:

    • A retrospective analysis of 237 medication orders for 30 drugs across 107 patients with varying renal function.

    Related Experiment Videos

  • Comparison of physician-prescribed doses against doses calculated by a computer program incorporating renal function.
  • Categorization of drugs into wide range, narrow range, and 80% renally excreted for analysis.

    • Main Results:

    • Significant overdosing was observed in patients with true renal impairment (serum creatinine ≥ 1.2 mg/100 ml, creatinine clearance < 80 ml/m).
    • Overdosing rates were particularly high for narrow range (83%) and 80% renally excreted (77%) agents.
    • Discrepancies highlight a potential hazard in current prescribing practices.

    Conclusions:

    • Physician dosing without considering renal function poses a significant risk of toxicity.
    • Utilizing creatinine clearance (estimated or measured) for dose adjustments is strongly recommended.
    • Implementing manufacturer recommendations or computer-assisted dosing can mitigate overdosing risks for renally cleared medications.