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Related Experiment Videos

The coagulation factor VII in pregnancy.

K Dalaker, H Prydz

    British Journal of Haematology
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Pregnancy increases blood clotting due to a complex involving factor VII. This complex’s activity is reduced by phospholipase C, suggesting a novel mechanism in pregnancy-related hypercoagulable states.

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    Area of Science:

    • Biochemistry
    • Hematology
    • Reproductive Biology

    Background:

    • Pregnancy is associated with a hypercoagulable state, increasing thrombosis risk.
    • Elevated plasma factor VII activity contributes to this hypercoagulable state.

    Purpose of the Study:

    • To investigate the nature of the increased factor VII activity during pregnancy.
    • To identify factors contributing to the hypercoagulable state in pregnancy.

    Main Methods:

    • Treatment of pregnant plasma with purified phospholipase C from Bacillus cereus.
    • Assessing the effect of phospholipase C on factor VII, factor II, and factor X activity.
    • Gel filtration (Sephadex G-100) to separate plasma components.

    Main Results:

    Related Experiment Videos

    • Phospholipase C reduced elevated factor VII activity in pregnant plasma to non-pregnant levels.
    • Phospholipase C did not affect factor II or factor X levels.
    • A novel, phospholipase C-sensitive complex of factor VII was identified in pregnant plasma.
    • This complex was partially separated from other factor VII forms via gel filtration.

    Conclusions:

    • The increased factor VII activity in pregnancy is due to a circulating complex sensitive to phospholipase C.
    • This finding reveals a novel mechanism contributing to the hypercoagulable state during pregnancy.
    • Further research into this complex may offer new therapeutic targets for pregnancy-related thrombosis.