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Observation on haematological patterns in pulmonary tuberculosis in Nigerians
The Journal of Tropical Medicine and Hygiene
|May 1, 1978
Summary
Pulmonary tuberculosis patients on anti-tuberculosis drugs showed improved packed cell volume (PCV) with oral iron supplements. Adding oral iron and folate to therapy is recommended for managing tuberculosis anemia.
Area of Science:
- Hematology
- Pulmonology
- Infectious Diseases
Background:
- Pulmonary tuberculosis (TB) can cause significant hematological changes.
- Anemia is a common comorbidity in TB patients, impacting treatment outcomes.
Purpose of the Study:
- To investigate the hematological patterns of pulmonary tuberculosis patients.
- To evaluate the effect of oral iron supplementation on hematological parameters in TB patients.
Main Methods:
- A study of 21 pulmonary tuberculosis cases at University College Hospital, Ibadan.
- Patients were divided into two groups: anti-TB drugs only, and anti-TB drugs plus oral iron.
- Hematological patterns were assessed at diagnosis and three months post-treatment.
Main Results:
- Patients receiving oral iron supplements showed a significant rise in packed cell volume (PCV).
- Megaloblastic bone marrow changes were observed in 20% of patients after three months.
- Seventy-five percent of patients presented with myeloid hyperplasia at diagnosis.
Conclusions:
- Oral iron supplementation appears beneficial for improving hematological parameters in pulmonary tuberculosis patients.
- Adding oral iron and folate to anti-tuberculosis therapy is suggested for comprehensive patient management.
- Further research into managing anemia in TB patients is warranted.