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Related Experiment Videos

Sandwich therapy in testis tumor: current experience.

D F Lynch, L P McCord, T C Nicholson

    The Journal of Urology
    |May 1, 1978
    PubMed
    Summary
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    Sandwich therapy for non-seminomatous testis tumors showed an 84% survival rate. However, due to severe side effects and better outcomes with other treatments, this approach is no longer standard.

    Area of Science:

    • Oncology
    • Surgical Oncology
    • Radiation Oncology

    Background:

    • Non-seminomatous testis tumors require effective treatment regimens.
    • Sandwich therapy, combining surgery and radiation, was previously used.
    • Assessing long-term outcomes and side effects is crucial for treatment optimization.

    Purpose of the Study:

    • To evaluate the efficacy and safety of sandwich therapy for non-seminomatous testis tumors.
    • To compare sandwich therapy outcomes with alternative treatment modalities.
    • To inform clinical practice regarding the standard of care for these tumors.

    Main Methods:

    • Retrospective analysis of 13 patients with stages A and B non-seminomatous testis tumors treated with sandwich therapy.
    • Review of historical data from 35 patients treated with the same regimen between 1958 and 1970.

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  • Documentation of survival rates and treatment-related side effects.

    • Main Results:

    • Sandwich therapy achieved an 84% survival rate in the current cohort, consistent with a previous 83% rate.
    • Significant side effects included bone marrow depression, retroperitoneal fibrosis, and potential secondary malignancies.
    • Alternative treatments (lymphadenectomy alone or with chemotherapy) demonstrated superior survival with fewer adverse events.

    Conclusions:

    • While sandwich therapy demonstrated a notable survival rate, its associated severe side effects are a concern.
    • The advent of more effective and less toxic treatments necessitates a shift away from sandwich therapy.
    • Discontinuation of sandwich therapy as a standard treatment for non-seminomatous testis tumors is recommended at this institution.