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In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)06:48

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)

This protocol describes in ovo xenografting of patient-derived B- and T-acute lymphoblastic leukemia (ALL) cells, which occurs 4 days following...
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Generation of Warfighter Avatars from Weapon Training Scene Images for Blast Exposure Simulations06:20

Generation of Warfighter Avatars from Weapon Training Scene Images for Blast Exposure Simulations

A computational framework was developed to automatically reconstruct virtual scenes comprising 3D avatars of soldiers using image and/or video data. The virtual scenes help estimate blast overpressure exposure during weapon training. The tool facilitates a realistic representation of human posture in blast exposure simulations in various...
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Modeling Highly Repetitive Low-level Blast Exposure in Mice06:00

Modeling Highly Repetitive Low-level Blast Exposure in Mice

Presented here are methods for producing repeated low-intensity blast exposures using...
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A Novel In Vitro Model of Blast Traumatic Brain Injury08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

This paper describes a novel model of primary blast traumatic brain injury. A compressed-air driven shock tube is used to expose in vitro mouse hippocampal slice cultures to a single shock wave. This is a simple and rapid protocol generating a reproducible brain tissue injury with a high throughput.
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Evaluating Primary Blast Effects In Vitro10:51

Evaluating Primary Blast Effects In Vitro

Understanding how cells are modulated by exposure to shock waves can help identify the mechanisms behind injuries triggered from blast events. This protocol uses custom-built shock tube equipment to apply shock waves at a range of pressures to cell monolayers and to identify the subsequent effects on cell...
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Blast Quantification Using Hopkinson Pressure Bars09:41

Blast Quantification Using Hopkinson Pressure Bars

This protocol details the use of Hopkinson pressure bars to measure reflected blast loading from near-field explosive events. It is capable of interpolating a pressure-time history at any point on a reflective boundary and as such can be used to fully characterize the spatial and temporal variations in loading...
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