Germinal center cell-derived lymphomas of the skin

Germinal center cell-derived (GCC) malignant lymphomas are B-cell tumors that represent neoplastic equivalents of normal lymphoid follicles. These lymphomas include, in the Kiel classification, three main types: centrocytic lymphoma, centroblastic-centrocytic lymphoma, and centroblastic lymphoma. We have diagnosed 13 cases of germinal center cell-derived cutaneous lymphomas among 178 evaluated malignant lymphomas of the skin. Some clinical, histologic, and immunologic aspects are discussed in this article.