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[Corticosteroids, non-steroidal antirheumatic agents and the gastroduodenum].
Zeitschrift Fur Rheumatologie
|January 1, 1984
Summary
Frequent use of acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs (NSAID) is linked to gastric ulcers and bleeding. While small ulcers may heal with treatment, larger ones are less likely to heal if NSAID or corticosteroid use continues.
Area of Science:
- Gastroenterology
- Pharmacology
Context:
- Nonsteroidal anti-inflammatory drugs (NSAID) and corticosteroids are widely used for pain and inflammation.
- Gastroduodenal mucosal damage is a significant concern associated with these medications.
Purpose:
- To review the damaging effects of acetylsalicylic acid, other NSAID, and corticosteroids on the gastroduodenal mucosa.
- To analyze blood loss studies and endoscopic findings related to drug-induced gastroduodenal injury.
Summary:
- Epidemiological data indicate a strong association between frequent acetylsalicylic acid intake and gastric ulcers/gastrointestinal bleeding.
- Evidence for the superiority of other NSAID over acetylsalicylic acid in causing gastroduodenal damage is limited.
- H2 receptor antagonists can promote healing of small ulcers (<1 cm) even with continued low-dose NSAID or corticosteroid use, but healing is poor for larger ulcers.
Impact:
- Highlights the risks of NSAID and corticosteroid use on the upper gastrointestinal tract.
- Informs clinical practice regarding ulcer management in patients on these medications.
- Emphasizes the need for careful consideration of perforation risk.