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[Clinico-immunologic correlations in disseminated sclerosis].

I A Zavalishin, O A Khondkarian, O M Nevskaia

    Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
    |January 1, 1984
    PubMed
    Summary

    Cellular and humoral immunity correlate with multiple sclerosis (MS) severity. Immune responses change during MS relapses and in progressive disease, suggesting personalized immunotherapy is needed.

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    [Compensatory mechanisms in multiple sclerosis(review)].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2013

    Area of Science:

    • Immunology
    • Neurology
    • Autoimmune Diseases

    Context:

    • Disseminated sclerosis (DS), also known as multiple sclerosis (MS), is a chronic autoimmune disease affecting the central nervous system.
    • Understanding the immune system's role in MS pathogenesis is crucial for developing effective treatments.

    Purpose:

    • To investigate the correlation between cellular and humoral immunity and the clinical presentation of disseminated sclerosis.
    • To identify specific immune markers associated with disease activity and progression in MS patients.

    Summary:

    • A study of 107 patients revealed that the intensity of cellular and humoral immunity correlates with the acuteness and severity of disseminated sclerosis.
    • During disease exacerbations, patients showed decreased T lymphocyte activity (via lymphocyte blast transformation) and altered antibody levels (high cerebral, low complement-fixing).
    • Reduced cellular reactivity was observed in patients with unfavorable, steadily progressing disease.

    Impact:

    • The findings highlight the necessity of a differential approach to immunotherapy for disseminated sclerosis.
    • Immune deviations in both cellular and humoral immunity should be considered for personalized MS treatment strategies.

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