Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrogen dioxide exposure--influence on rat testes.

B J Kripke, R P Sherwin

    Anesthesia and Analgesia
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A novel snake venom disintegrin that inhibits human ovarian cancer dissemination and angiogenesis in an orthotopic nude mouse model.

    Haemostasis·2002
    Same author

    Centriacinar region inflammatory disease in young individuals: a comparative study of Miami and Los Angeles residents.

    Virchows Archiv : an international journal of pathology·2000
    Same author

    Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression.

    Breast cancer research and treatment·2000
    Same author

    Chronic glandular bronchitis in young individuals residing in a metropolitan area.

    Virchows Archiv : an international journal of pathology·1998
    Same author

    Air pollution: the pathobiologic issues.

    Journal of toxicology. Clinical toxicology·1991
    Same author

    Desquamative interstitial pneumonia in an infant. Mimicry of sudden infant death syndrome.

    The American journal of forensic medicine and pathology·1989
    Same journal

    Incomplete Recovery of Diaphragmatic Mechanics at a Train-of-Four Ratio of 0.90 to <0.95 Assessed by Dynamic Digital Radiography: A Proof-of-Concept Case Series.

    Anesthesia and analgesia·2026
    Same journal

    Patients' Perspectives and Experiences of Participating in Anesthesia Research: A Qualitative Study.

    Anesthesia and analgesia·2026
    Same journal

    Impact of Epidural-Related Maternal Fever on Neonatal Outcomes: A Single-Center Retrospective Case-Control Study Excluding Confirmed Histological Chorioamnionitis.

    Anesthesia and analgesia·2026
    Same journal

    Patient Beliefs and Experiences of Adhering to Medical Therapies for Cardiovascular Comorbidities, Before Noncardiac Elective Surgery in South Africa: A Mixed-Methods Study.

    Anesthesia and analgesia·2026
    Same journal

    Beyond Administrative Indices: Allostatic Load and Autonomic Dyshomeostasis as Biological Mediators of Intraoperative Cardiac Arrest.

    Anesthesia and analgesia·2026
    Same journal

    In Response.

    Anesthesia and analgesia·2026
    See all related articles

    Nitrogen dioxide (NO2) exposure did not impair rat spermatogenesis or alter vitamin B12 levels. This study investigated potential health effects of NO2 impurities in medical nitrous oxide (N2O).

    Area of Science:

    • Toxicology
    • Reproductive Biology
    • Environmental Health

    Background:

    • Medical nitrous oxide (N2O) may contain nitrogen dioxide (NO2) impurities.
    • NO2 has known biological toxicity, raising concerns about N2O's safety.
    • Previous studies suggest N2O impairs spermatogenesis.

    Purpose of the Study:

    • To determine if NO2 exposure, at concentrations found in medical N2O, affects rat spermatogenesis.
    • To assess the impact of NO2 on serum vitamin B12 levels.

    Main Methods:

    • Rats were exposed to 1 ppm NO2 for 7 hours/day, 5 days/week, over 21 days.
    • Testicular tissues were examined for abnormalities using gross and light microscopy.
    • Serum vitamin B12 levels were measured.

    Related Experiment Videos

    Main Results:

    • No gross or light microscopy abnormalities were observed in the testes of NO2-exposed rats.
    • Serum vitamin B12 levels remained within normal limits in the exposed group.
    • NO2 exposure at 1 ppm did not induce observable toxicity in the testes.

    Conclusions:

    • NO2 exposure at 1 ppm under these experimental conditions does not impair rat spermatogenesis.
    • NO2 does not appear to affect vitamin B12 levels relevant to spermatogenesis.
    • The study suggests NO2 impurities in medical N2O may not pose a significant risk to male reproductive health at tested levels.