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Cefuroxime treatment of bacterial meningitis in infants and children

S Sirinavin, S Chiemchanya, P Visudhipan

    Antimicrobial Agents and Chemotherapy
    |February 1, 1984
    PubMed

    Insights

    Cefuroxime effectively treated meningitis caused by drug-resistant Haemophilus influenzae type b and Salmonella strains in children. This antibiotic shows promise as an alternative therapy for these serious infections.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Pediatrics

    Background:

    • Emergence of ampicillin- and chloramphenicol-resistant Haemophilus influenzae type b and multiply-resistant Salmonella strains necessitates alternative treatments.
    • Bacterial meningitis remains a significant global health concern, particularly in pediatric populations.

    Purpose of the Study:

    • To evaluate the efficacy and safety of cefuroxime in treating pediatric meningitis caused by antibiotic-resistant bacteria.
    • To determine cefuroxime concentrations in cerebrospinal fluid and subdural fluid during treatment.

    Main Methods:

    • Clinical case series involving seven children diagnosed with meningitis.
    • Treatment with cefuroxime at 200-250 mg/kg/day in four divided doses for 14-21 days.
    • Measurement of cefuroxime levels in cerebrospinal fluid and subdural fluid.

    Main Results:

    • Successful treatment outcomes were observed in all five children with H. influenzae type b meningitis and two children with Salmonella meningitis.
    • Cefuroxime achieved therapeutic concentrations in cerebrospinal fluid, exceeding levels in non-meningitis patients.
    • Adequate cefuroxime concentrations were also found in subdural fluid samples.

    Conclusions:

    • Cefuroxime is a recommended alternative therapy for meningitis caused by H. influenzae type b, especially resistant strains.
    • Further research is needed to establish cefuroxime's role in treating Salmonella meningitis.

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