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Related Concept Videos

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Related Experiment Video

Updated: Jul 9, 2026

Assessing the Secretory Capacity of Pancreatic Acinar Cells
09:52

Assessing the Secretory Capacity of Pancreatic Acinar Cells

Published on: August 28, 2014

Value of serum PABA as a pancreatic function test.

C Lang, K Gyr, I Tonko

    Gut
    |May 1, 1984
    PubMed
    Summary

    This study found that measuring para-aminobenzoic acid (PABA) in the blood two hours after taking N-benzoyl-L-tyrosyl-PABA (BT-PABA) effectively assesses pancreatic function, similar to urinary PABA tests.

    Area of Science:

    • Gastroenterology
    • Biochemistry
    • Diagnostic Medicine

    Background:

    • Pancreatic exocrine insufficiency affects nutrient absorption.
    • Accurate pancreatic function tests are crucial for diagnosis.
    • N-benzoyl-L-tyrosyl-PABA (BT-PABA) is an oral substrate used to assess pancreatic enzyme activity.

    Purpose of the Study:

    • To evaluate the diagnostic value of serum para-aminobenzoic acid (PABA) levels after BT-PABA administration for pancreatic function.
    • To compare serum PABA determination with urinary PABA excretion as a pancreatic function index.

    Main Methods:

    • An oral pancreatic function test using BT-PABA was administered to 71 subjects (19 controls, 24 non-pancreatic GI disease, 27 pancreatic disease).
    • Serum PABA concentrations and urinary PABA excretion were measured simultaneously.

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  • Statistical analysis compared results between groups and assessed diagnostic discrimination.

    • Main Results:

    • Urinary PABA excretion was significantly lower in patients with chronic pancreatitis and pancreatic carcinoma (p < 0.001).
    • Serum PABA concentration curves were significantly flattened in chronic pancreatitis patients (p < 0.001).
    • Serum PABA measurement at 120 minutes showed strong discrimination between controls and chronic pancreatitis patients (lower limit of normal: 2.8 µg/ml).

    Conclusions:

    • Serum PABA concentration determination two hours post-BT-PABA administration is a valuable pancreatic function test.
    • This method offers comparable diagnostic utility to urinary PABA excretion analysis.
    • The BT-PABA test provides a reliable non-invasive assessment of pancreatic exocrine function.