Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Self tolerance is H-2-restricted.

P Matzinger, R Zamoyska, H Waldmann

    Nature
    |April 19, 1984
    PubMed
    Summary
    This summary is machine-generated.

    T-cell tolerance induction to self minor histocompatibility (H) antigens is H-2 restricted. This finding challenges previous assumptions and suggests H-2 restriction may be a broader principle in T-cell responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Does the Danger model shed any light on central tolerance?: A response to Al-Yassin.

    Scandinavian journal of immunology·2018
    Same author

    Transplantation tolerance: the big picture. Where do we stand, where should we go?

    Clinical and experimental immunology·2017
    Same author

    Remission Induction in Patients with Lymphoid Malignancies Using Unconjugated CAMPATH-1 Monoclonal Antibodies.

    Leukemia & lymphoma·2016
    Same author

    Limiting dilution analysis of the cells of immune system I. The clonal basis of the immune response.

    Immunology today·2014
    Same author

    Limiting dilution analysis of cells of the immune system II: What can be learnt?

    Immunology today·2014
    Same author

    Advantages of rat monoclonal antibodies.

    Immunology today·2014
    Same journal

    Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

    Nature·2026
    Same journal

    China boosts prestigious grants for young scientists - will it ease competition?

    Nature·2026
    Same journal

    Incoming US science academy chief vows to 'double down' on research.

    Nature·2026
    Same journal

    Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

    Nature·2026
    Same journal

    Electrodeposited self-assembled molecules for perovskite photovoltaics.

    Nature·2026
    Same journal

    Neutrino's nursery found: the 'Shadow Blaster'.

    Nature·2026
    See all related articles

    Area of Science:

    • Immunology
    • T-cell biology
    • Major Histocompatibility Complex (MHC) research

    Background:

    • T-cell activation is known to be restricted by the mouse H-2 major histocompatibility complex.
    • Previous studies on T-cell tolerance induction yielded inconclusive results regarding H-2 restriction.
    • Antigen processing by the host can mask H-2 restriction in T-cell activation.

    Purpose of the Study:

    • To investigate whether T-cell tolerance induction is also H-2 restricted.
    • To clarify the role of H-2 restriction in the development of self-tolerance.
    • To re-evaluate previous findings on T-cell tolerance in light of antigen processing.

    Main Methods:

    • Designed experiments to minimize antigen processing during tolerance induction.
    • Utilized minor histocompatibility (H) antigens to study self-tolerance.

    Related Experiment Videos

  • Assessed T-cell responses in an H-2 restricted context.

    • Main Results:

    • Demonstrated that T-cell tolerance induction to self minor H antigens is H-2 restricted.
    • Provided evidence that H-2 restriction can be masked by antigen processing.
    • Contradicted previous inconclusive findings on H-2 restriction in tolerance.

    Conclusions:

    • T-cell tolerance induction is an H-2 restricted process.
    • H-2 restriction is a fundamental characteristic of T-cell responses, encompassing both activation and tolerance.
    • Minimizing antigen processing is crucial for observing H-2 restriction in tolerance induction.