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Related Experiment Videos

Lymphocyte function in major depressive disorder.

S J Schleifer, S E Keller, A T Meyerson

    Archives of General Psychiatry
    |May 1, 1984
    PubMed
    Summary

    Depressed patients showed significantly lower lymphocyte stimulation responses to common mitogens. This immune cell dysfunction, including reduced T and B cell counts, may link to neuroendocrine changes in depression.

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    Myelination, oligodendrocytes, and serious mental illness.

    Glia·2014

    Area of Science:

    • Immunology
    • Neuroscience
    • Psychiatry

    Background:

    • Depression is associated with various physiological changes.
    • Immune system dysregulation is increasingly recognized in psychiatric disorders.

    Purpose of the Study:

    • To investigate lymphocyte function in hospitalized patients with depression.
    • To compare immune cell responses between depressed patients and healthy controls.

    Main Methods:

    • Assessed lymphocyte stimulation responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen.
    • Quantified absolute numbers and percentages of T and B cells.

    Main Results:

    • Significantly lower lymphocyte stimulation in depressed patients compared to controls.

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  • Reduced absolute counts of T and B lymphocytes in the depressed group.
  • No significant difference in the percentage of T and B cells between groups.

    • Conclusions:

    • Depression is linked to impaired lymphocyte responsiveness.
    • Findings suggest potential immune system alterations contributing to depressive disorders.
    • Neuroendocrine dysfunction may play a role in observed immune changes.