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Related Experiment Videos

Brain reward circuitry: a case for separate systems.

A G Phillips

    Brain Research Bulletin
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Brain reward pathways are complex, involving multiple systems. Dopamine pathways in the forebrain and hindbrain trigeminal systems contribute to reward, influencing motor control and mood.

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    Area of Science:

    • Neuroscience
    • Neurobiology
    • Reward System Research

    Background:

    • Intracranial self-stimulation (ICSS) provides a model for studying brain reward mechanisms.
    • Previous research suggests multiple, independent substrates contribute to brain-stimulation reward.
    • Understanding these substrates is crucial for elucidating the neurobiology of reward and motivation.

    Purpose of the Study:

    • To review anatomical, lesion, and pharmacological data on ICSS.
    • To identify distinct subsystems involved in brain-stimulation reward.
    • To explore the roles of specific neural pathways, including dopamine systems, in reward processes.

    Main Methods:

    • Review of existing anatomical studies.
    • Analysis of lesion data to determine critical brain regions for reward.

    Related Experiment Videos

  • Pharmacological investigations of neurotransmitter involvement in ICSS.
  • Integration of data to propose functional subsystems of reward.

    • Main Results:

    • Identification of multiple independent subsystems for brain-stimulation reward.
    • Delineation of subsystems linked to chemosensitive pathways, motor control, and mood.
    • Evidence supporting the role of forebrain dopamine pathways in two separate reward subsystems.
    • Nigrostriatal dopamine (DA) neurons associated with response initiation via extrapyramidal circuits.
    • Mesolimbic DA pathway potentially involved in positive affect control and perception.
    • A hindbrain trigeminal system identified as a potential independent reward substrate.

    Conclusions:

    • Brain reward is mediated by multiple, interacting subsystems.
    • Dopamine pathways play critical, distinct roles in different aspects of reward.
    • The mesolimbic and nigrostriatal dopamine systems are key components of forebrain reward circuitry.
    • The trigeminal system represents a potential novel, independent pathway for reward processing.