Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Alloreactive T cell clones.

Advances in Experimental Medicine and Biology

|January 1, 1984

Summary

This summary is machine-generated.

T cell clones reveal unexpected dual reactivity, suggesting T cells may recognize multiple antigens. These homogeneous models are crucial for understanding T cell receptor function and immune modulation by secreted factors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diagnosis and treatment of mycoplasma-contaminated cell cultures.

Current protocols in immunology·2008

Same author

B7.1 is a quantitatively stronger costimulus than B7.2 in the activation of naive CD8+ TCR-transgenic T cells.

Journal of immunology (Baltimore, Md. : 1950)·1998

Same author

Notice of duplicate publication.

Journal of immunology (Baltimore, Md. : 1950)·1998

Same author

IL-4 enhances long-term survival of CD28-deficient T cells.

Journal of immunology (Baltimore, Md. : 1950)·1998

Same author

CD28 costimulation promotes the production of Th2 cytokines.

Journal of immunology (Baltimore, Md. : 1950)·1997

Same author

Control of T lymphocyte signal transduction through clonal anergy.

Journal of molecular medicine (Berlin, Germany)·1996

Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026

Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026

Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026

Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026

Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026

Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026

See all related articles

Area of Science:

Immunology
Cell Biology

Background:

T cell clones serve as valuable models for studying lymphocyte function.
Derivation and maintenance methods can significantly impact T cell clone characteristics.

Purpose of the Study:

To investigate the properties and potential dual reactivity of murine T cell clones.
To explore the role of T cell clones in understanding T cell receptor function and immune modulation.

Main Methods:

Generation and characterization of murine cytolytic and non-cytolytic T cell clones.
Analysis of T cell clone reactivity and secreted factors.

Main Results:

A high proportion of T cell clones exhibit dual reactivity, challenging the notion of absolute cytolytic or non-cytolytic distinctions.

Related Experiment Videos

Culture supernatants from T cell clones contain factors (e.g., IL-2, BCSF, IL-3, CSF, Interferon) that modulate various immune cells, including B cells, macrophages, and natural killer cells.

Conclusions:

T cell clones, despite potential dual reactivity, are essential for dissecting T cell receptor complexity and antigen recognition.
Activated T cells secrete diverse factors that play significant roles in modulating both innate and adaptive immune responses.