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Related Experiment Videos

Perfluorocarbon infusion in bleeding patients refusing blood transfusions.

K Waxman, K K Tremper, B F Cullen

    Archives of Surgery (Chicago, Ill. : 1960)
    |June 1, 1984
    PubMed
    Summary

    Perfluorochemical (PFC) emulsion improved oxygen delivery in anemic patients but caused adverse effects. Dissolved oxygen in PFC significantly contributed to oxygen consumption, indicating enhanced microcirculation.

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    Area of Science:

    • Biomedical Engineering
    • Anesthesiology
    • Critical Care Medicine

    Background:

    • Severe anemia poses challenges in surgical patients, particularly those refusing blood transfusions.
    • Perfluorochemical (PFC) emulsions are artificial oxygen carriers investigated as alternatives to blood products.

    Purpose of the Study:

    • To evaluate the efficacy and safety of Fluosol-DA 20%, a PFC emulsion, in severely anemic surgical patients who declined blood transfusions.
    • To assess the impact of PFC emulsion on oxygen transport and consumption in a clinical setting.

    Main Methods:

    • Six severely anemic surgical patients received Fluosol-DA 20% (PFC emulsion).
    • High inspired oxygen concentrations were administered to assess oxygen transport dynamics.
    • Arterial oxygen content and oxygen consumption were measured.

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  • The contribution of dissolved oxygen in PFC to oxygen consumption was quantified.

    • Main Results:

    • Fluosol-DA 20% led to moderate increases in arterial oxygen content.
    • Oxygen consumption increased considerably, suggesting improved oxygen distribution to tissues.
    • Dissolved oxygen in PFC accounted for 22% +/- 5% of consumed oxygen.
    • In PFC plus plasma emulsions, dissolved oxygen contributed 60% +/- 12% to oxygen consumption.
    • Adverse effects included transient leukopenia, hypotension, and abnormal liver and lung function.

    Conclusions:

    • PFC emulsions can enhance oxygen delivery and consumption in anemic surgical patients.
    • While showing potential for improved microcirculatory oxygen distribution, PFC emulsions are associated with significant adverse clinical effects.
    • Further research is needed to optimize PFC emulsion safety and efficacy for clinical use.