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Keratoconus with pellucid marginal corneal degeneration
Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 1, 1984
Summary
Pellucid marginal corneal degeneration may be a form of keratoconus. Some patients with pellucid degeneration also showed keratoconus, suggesting a shared cause or variant presentation for these corneal conditions.
Area of Science:
- Ophthalmology
- Corneal Diseases
- Genetics
Background:
- Keratoconus and pellucid marginal corneal degeneration are distinct corneal ectatic disorders.
- Understanding the relationship between these conditions is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the co-occurrence of keratoconus and pellucid marginal corneal degeneration.
- To explore whether these conditions represent variants of a single disease entity.
Main Methods:
- Retrospective examination of 1,625 Japanese patients diagnosed with keratoconus.
- Analysis of 20 patients diagnosed with pellucid marginal corneal degeneration.
Main Results:
- 17 out of 20 patients with pellucid marginal corneal degeneration also exhibited keratoconus in the central cornea.
- Three patients with pellucid degeneration but without keratoconus showed bilateral involvement.
- Among the 17 cases with both conditions, eight had bilateral involvement and nine had unilateral involvement.
Conclusions:
- Pellucid marginal corneal degeneration, with or without co-existing keratoconus, might be a variant of keratoconus.
- These conditions may arise from the same underlying etiologic factor.
- Further research is warranted to elucidate the precise relationship and shared etiology.