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Activated complement in inflamed aqueous humor.

B J Mondino, M M Glovsky, L Ghekiere

    Investigative Ophthalmology & Visual Science
    |July 1, 1984
    PubMed
    Summary
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    Activated complement fragments, including C3a, are present in the aqueous humor of eyes with anterior uveitis. These findings suggest the complement system may play a role in mediating ocular inflammation.

    Area of Science:

    • Immunology
    • Ophthalmology

    Background:

    • The complement system is a crucial part of innate immunity.
    • Activated complement components mediate inflammatory responses.
    • The role of complement in anterior uveitis is not fully understood.

    Purpose of the Study:

    • To investigate the presence and activation of complement components in the aqueous humor of patients with anterior uveitis.
    • To determine if complement activation correlates with ocular inflammation.

    Main Methods:

    • Radioimmunoassay was used to quantify C3a levels in aqueous humor.
    • Immunoelectrophoresis was employed to detect Factor B, Bb, and C3c in aqueous humor samples.

    Main Results:

    • Normal aqueous humor lacked detectable C3a, C3c, or Factor B.

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  • All aqueous humor samples from patients with anterior uveitis showed measurable C3a levels.
  • Factor B and C3c were detected in a subset of inflamed samples, with evidence of alternative pathway activation (Factor B to Bb conversion).

    • Conclusions:

    • Activated complement fragments are present in the aqueous humor during anterior uveitis.
    • Complement activation, particularly via the alternative pathway, may contribute to the inflammatory process in the eye.