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Exocrine pancreatic function in diabetic children.

M Sato, K Yamamoto, H Mayama

    Journal of Pediatric Gastroenterology and Nutrition
    |June 1, 1984
    PubMed
    Summary

    Diabetic children show reduced exocrine pancreatic function, impacting digestion. This may be an early functional disturbance, not permanent tissue damage, in pediatric diabetes.

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    Area of Science:

    • Pediatric Endocrinology
    • Gastroenterology
    • Metabolic Disorders

    Background:

    • Diabetes mellitus can affect various organ systems.
    • Exocrine pancreatic function is crucial for digestion.
    • Subtle pancreatic changes in pediatric diabetes are not well understood.

    Purpose of the Study:

    • To assess exocrine pancreatic function in children with diabetes.
    • To identify potential early functional disturbances.
    • To correlate pancreatic function with diabetes duration.

    Main Methods:

    • Evaluated 19 diabetic children and controls.
    • Utilized pancreozymin-secretin tests.
    • Assessed p-aminobenzoic acid (PABA) test and plasma trypsin/elastase-1 levels.

    Main Results:

    • Diabetic children showed lower duodenal fluid volume, bicarbonate, and amylase output.
    • Reduced PABA test results and plasma trypsin/elastase-1 levels were observed in diabetics.
    • No correlation with diabetes duration, but prolonged diabetes (>1 year) linked to severe dysfunction.

    Conclusions:

    • Diabetic children exhibit impaired exocrine pancreatic function.
    • Early-stage functional disturbance is suggested over anatomical loss.
    • Further investigation into the pathophysiology of pancreatic dysfunction in pediatric diabetes is warranted.

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