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HLA-B27 and allotypes of complement components in ankylosing spondylitis
The Journal of Rheumatology
|June 1, 1984
Summary
This study investigated the genetic links between ankylosing spondylitis (AS) and human leukocyte antigen B27 (HLA-B27). Results suggest HLA-B27 or a nearby gene may predispose individuals to developing AS.
Area of Science:
- Immunogenetics
- Rheumatology
- Human Genetics
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease.
- The human leukocyte antigen B27 (HLA-B27) is strongly associated with AS.
- Complement system components (C2, C4, Bf) play roles in immune responses.
Purpose of the Study:
- To investigate the frequency of HLA-B27 and complement allotypes in families with AS.
- To determine if specific complement allotypes are associated with HLA-B27 in AS patients.
Main Methods:
- Studied 13 families with definite ankylosing spondylitis (AS) based on New York criteria.
- Analyzed the frequency of HLA-B27.
- Determined the allotypes of complement components C2, C4, and Bf.
Main Results:
- HLA-B27 positive haplotypes in AS patients showed variations in complement allotypes.
- Specific associations between HLA-B27 and certain complement allotypes were observed in the studied families.
Conclusions:
- The gene predisposing to ankylosing spondylitis may be HLA-B27 itself.
- Alternatively, a gene closely linked to the HLA-B locus could confer AS predisposition.