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Related Experiment Videos

Circulating immune complexes in Yersinia infection.

M Leirisalo, M Gripenberg, I Julkunen

    The Journal of Rheumatology
    |June 1, 1984
    PubMed
    Summary
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    Circulating immune complexes (CIC) are present in Yersinia arthritis patients and often in Yersinia enteritis (YE) without joint issues. This suggests CIC are linked to YE, regardless of arthritis development.

    Area of Science:

    • Immunology
    • Rheumatology
    • Gastroenterology

    Background:

    • Yersinia enteritis (YE) can cause reactive arthritis.
    • The role of circulating immune complexes (CIC) in YE and associated arthritis is not fully understood.

    Purpose of the Study:

    • To investigate the presence and significance of CIC in patients with Yersinia arthritis and uncomplicated Yersinia enteritis.

    Main Methods:

    • Utilized the platelet-iodinated protein A (PIPA) technique.
    • Employed a solid phase Clq-binding enzyme-linked immunosorbent assay (ELISA).
    • Studied 9 patients with Yersinia arthritis and 7 with YE without extraintestinal symptoms.

    Main Results:

    • CIC were detected in all acute Yersinia arthritis cases and in 3 post-recovery.

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  • CIC were found in 5 out of 7 patients with uncomplicated YE.
  • Both PIPA and Clq-binding ELISA techniques confirmed CIC presence.

    • Conclusions:

    • Circulating immune complexes are associated with Yersinia enteritis, even without arthritis.
    • CIC detection may serve as a marker for YE, irrespective of joint involvement.