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Trimethoprim sulphamethoxazole in neonatal Flavobacterium meningosepticum infection

N Linder, S H Korman, F Eyal

    Archives of Disease in Childhood
    |June 1, 1984
    PubMed

    Insights

    Trimethoprim-sulfamethoxazole effectively treated Flavobacterium meningosepticum sepsis in neonates, achieving an 89% cure rate with minimal side effects. This antibiotic is a viable option for neonatal intensive care units facing F. meningosepticum outbreaks.

    Area of Science:

    • Neonatal intensive care
    • Infectious diseases
    • Pharmacology

    Background:

    • Neonatal intensive care units (NICUs) can experience outbreaks of serious bacterial infections.
    • Flavobacterium meningosepticum is a pathogen that can cause severe sepsis in neonates.
    • Effective antibiotic treatment options for neonatal sepsis are crucial.

    Purpose of the Study:

    • To evaluate the efficacy and safety of intravenous trimethoprim-sulfamethoxazole for treating Flavobacterium meningosepticum sepsis in neonates.
    • To assess the clinical and bacteriological outcomes of this treatment regimen.

    Main Methods:

    • A retrospective study of 9 infants treated with intravenous trimethoprim-sulfamethoxazole during an F. meningosepticum outbreak.
    • Monitoring of clinical response, bacteriological eradication, and adverse events.

    Main Results:

    • Bacteriological cure was achieved in 8 out of 9 infants (89%).
    • One infant died due to massive intraventricular hemorrhage unrelated to the treatment.
    • No significant side effects were observed, apart from prolonged thrombocytopenia in one case.

    Conclusions:

    • Intravenous trimethoprim-sulfamethoxazole demonstrates high efficacy in treating neonatal F. meningosepticum sepsis.
    • The drug is well-tolerated in neonates and possesses favorable pharmacokinetic properties, including blood-brain barrier penetration.
    • Trimethoprim-sulfamethoxazole should be considered a valuable therapeutic option for neonatal sepsis caused by F. meningosepticum.

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