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H-Y antigen in human X-autosome translocations
Acta Anthropogenetica
|January 1, 1983
Abstract:
The distal segment of the X chromosome short arm (Xp223) escapes X-inactivation in the normal female. This was shown by the activity of three genes assigned to this segment, those for Xg, STS, and H-YB. In contrast, in cases with non-random X-inactivation due to structural aberration of one X chromosome, the genes for Xg and STS may undergo inactivation. In this article, it is shown that in X-autosome translocation, the H-YB gene which modifies the activity of H-Y antigen, may be inactivated as well. Evidence is presented that in these cases, expression of all three genes on Xp223 is concordant.