Related Experiment Videos
[Cerebral emission computer tomography (SPECT) with 123I-labeled amphetamines]
Deutsche Medizinische Wochenschrift (1946)
|July 27, 1984
Summary
Single-photon emission computed tomography (SPECT) using iodine-123-labeled amphetamines can image brain function. This technique detects perfusion disorders not visible with computed tomography (CT) in epilepsy, cerebrovascular disease, and migraine patients.
Area of Science:
- Neurology
- Nuclear Medicine
- Radiology
Background:
- Amphetamine uptake by brain tissue allows for scintigraphic imaging.
- Single-photon emission computed tomography (SPECT) is a key imaging modality.
Purpose of the Study:
- To evaluate the utility of SPECT with 123I-N-isopropyl-amphetamine for detecting functional brain disorders.
- To compare SPECT findings with cranial computed tomography (CT) in patients with neurological conditions.
Main Methods:
- 60 scintigraphic investigations were performed on 54 patients using a rotating gamma-camera SPECT scanner.
- 123I-N-isopropyl-amphetamine was administered for imaging.
Main Results:
- SPECT identified epileptic foci in 6/24 patients with normal CT.
- Diminished perfusion was detected in 4/25 patients with cerebrovascular disease and normal CT.
- Functional lesion extent in SPECT was larger than CT in 10/20 cases.
- SPECT revealed perfusion disorders in 3 migraine patients with normal CT, correlating with EEG findings.
Conclusions:
- Brain SPECT with 123I-labeled amphetamines detects functional and metabolic brain disorders not apparent on CT.
- SPECT provides a more precise assessment of functional lesion extent compared to CT.